p53 expression confers sensitivity to 5-fluorouracil via distinct chromatin accessibility dynamics in human colorectal cancer

One of the most commonly used drugs in chemotherapy, 5-fluorouracil (5-FU) has been shown to be effective in only 10–15% of patients with colon cancer. Thus, studies of the mechanisms affecting 5-FU sensitivity in these patients are necessary. The tumor suppressor protein p53 is a transcription fact...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Chul Min, Kang, Moo-Koo, Jung, Woong-Jae, Joo, Jung-Sik, Kim, Yong-Jin, Choi, Yeeun, Kim, Hyoung-Pyo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856692/
https://www.ncbi.nlm.nih.gov/pubmed/33613715
http://dx.doi.org/10.3892/ol.2021.12487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856692/
https://www.ncbi.nlm.nih.gov/pubmed/33613715
http://dx.doi.org/10.3892/ol.2021.12487

Ejemplares similares