Cargando…

p53 expression confers sensitivity to 5-fluorouracil via distinct chromatin accessibility dynamics in human colorectal cancer

One of the most commonly used drugs in chemotherapy, 5-fluorouracil (5-FU) has been shown to be effective in only 10–15% of patients with colon cancer. Thus, studies of the mechanisms affecting 5-FU sensitivity in these patients are necessary. The tumor suppressor protein p53 is a transcription fact...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Chul Min, Kang, Moo-Koo, Jung, Woong-Jae, Joo, Jung-Sik, Kim, Yong-Jin, Choi, Yeeun, Kim, Hyoung-Pyo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856692/ https://www.ncbi.nlm.nih.gov/pubmed/33613715 http://dx.doi.org/10.3892/ol.2021.12487

Ejemplares similares

CTCF-mediated chromatin looping provides a topological framework for the formation of phase-separated transcriptional condensates
por: Lee, Ryanggeun, et al.
Publicado: (2021)

Epigenome mapping highlights chromatin-mediated gene regulation in the protozoan parasite Trichomonas vaginalis
por: Song, Min-Ji, et al.
Publicado: (2017)

Liver-Specific Deletion of Mouse CTCF Leads to Hepatic Steatosis via Augmented PPARγ Signaling
por: Choi, Yeeun, et al.
Publicado: (2021)

Overexpression of CREPT confers colorectal cancer sensitivity to fluorouracil
por: Kuang, Yan-Shen, et al.
Publicado: (2018)

Regulation of the Boundaries of Accessible Chromatin
por: Chai, Xiaoran, et al.
Publicado: (2013)

Integrated Chromatin Accessibility and Transcriptome Landscapes of 5-Fluorouracil-Resistant Colon Cancer Cells
por: Zhang, Bishu, et al.
Publicado: (2022)

Differential chromatin accessibility landscape of gain-of-function mutant p53 tumours
por: Dhaka, Bhavya, et al.
Publicado: (2021)

Second-Line Irinotecan, Leucovorin, and 5-Fluorouracil for Gastric Cancer Patients after Failed Docetaxel and S-1
por: Jung, Joo Young, et al.
Publicado: (2016)

Amentoflavone Induces Autophagy and Modulates p53
por: Park, Hye-Jung, et al.
Publicado: (2019)

JNK confers 5-fluorouracil resistance in p53-deficient and mutant p53-expressing colon cancer cells by inducing survival autophagy
por: Sui, Xinbing, et al.
Publicado: (2014)

p53 binding sites in normal and cancer cells are characterized by distinct chromatin context
por: Bao, Feifei, et al.
Publicado: (2017)

Improved potency of F10 relative to 5-fluorouracil in colorectal cancer cells with p53 mutations
por: Dominijanni, Anthony, et al.
Publicado: (2018)

Comparative lipidomics of 5-Fluorouracil–sensitive and –resistant colorectal cancer cells reveals altered sphingomyelin and ceramide controlled by acid sphingomyelinase (SMPD1)
por: Jung, Jae Hun, et al.
Publicado: (2020)

p53 mutations define the chromatin landscape to confer drug tolerance in pancreatic cancer
por: Zampieri, Carlotta, et al.
Publicado: (2022)

p53 Enhances Artemisia annua L. Polyphenols-Induced Cell Death Through Upregulation of p53-Dependent Targets and Cleavage of PARP1 and Lamin A/C in HCT116 Colorectal Cancer Cells
por: Jung, Eun Joo, et al.
Publicado: (2020)

A Case of Severe Coronary Spasm Associated with 5-Fluorouracil Chemotherapy
por: Kim, Sang-Min, et al.
Publicado: (2012)

The effects of vascular access types on the survival and quality of life and depression in the incident hemodialysis patients
por: Kim, Do Hyoung, et al.
Publicado: (2019)

Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells
por: Park, Deokbae, et al.
Publicado: (2022)

Vorinostat-induced acetylation of RUNX3 reshapes transcriptional profile through long-range enhancer-promoter interactions in natural killer cells
por: Lee, Eun-Chong, et al.
Publicado: (2023)

Genetic factors underlying discordance in chromatin accessibility between monozygotic twins
por: Kim, Kwoneel, et al.
Publicado: (2014)

Tumor suppressor Parkin induces p53-mediated cell cycle arrest in human lung and colorectal cancer cells
por: Jung, Byung Chul, et al.
Publicado: (2023)

Retraction Note: JNK confers 5-fluorouracil resistance in p53-deficient and mutant p53-expressing colon cancer cells by inducing survival autophagy
por: Sui, Xinbing, et al.
Publicado: (2021)

ATAC‐seq exposes differences in chromatin accessibility leading to distinct leaf shapes in mulberry
por: Wang, Lei, et al.
Publicado: (2022)

A Randomized Trial Comparing Cisplatin Plus 5-fluorouracil With or Without Levamisole in Operable Gastric Cancer
por: Choi, Jong Soo, et al.
Publicado: (1997)

Quinacrine-Mediated Inhibition of Nrf2 Reverses Hypoxia-Induced 5-Fluorouracil Resistance in Colorectal Cancer
por: Kim, Ha Gyeong, et al.
Publicado: (2019)

TP53 engagement with the genome occurs in distinct local chromatin environments via pioneer factor activity
por: Sammons, Morgan A., et al.
Publicado: (2015)

Advanced Gastric Carcinoma Chemotherapy with Cisplatin, Mitomycin C, BCNU, and 5-Fluorouracil in Combination
por: Kim, Re Hwe, et al.
Publicado: (1987)

Genetic Landscape of Open Chromatin in Yeast
por: Lee, Kibaick, et al.
Publicado: (2013)

Comparison of capecitabine and 5-fluorouracil in chemoradiotherapy for locally advanced pancreatic cancer
por: Kim, Yeon-Joo, et al.
Publicado: (2013)

Chromatin dysregulation by mutant p53
por: Pfister, Neil T., et al.
Publicado: (2016)

53BP1 Sensitizes Breast Cancer Cells to 5-Fluorouracil
por: Li, Xiaoyan, et al.
Publicado: (2013)

Rapid genome-scale mapping of chromatin accessibility in tissue
por: Grøntved, Lars, et al.
Publicado: (2012)

Increased risk of gastric cancer in workers with occupational dust exposure
por: Kang, Mo-Yeol, et al.
Publicado: (2021)

Prognostic Factors of Survival with Aflibercept and FOLFIRI (fluorouracil, leucovorin, irinotecan) as Second-line Therapy for Patients with Metastatic Colorectal Cancer
por: Kim, Jinchul, et al.
Publicado: (2021)

Relationship between Bone Mineral Density and Moderate to Severe Chronic Kidney Disease among General Population in Korea
por: Myong, Jun-Pyo, et al.
Publicado: (2013)

Data on the Characteristics and the Survival of Korean Patients With Colorectal Cancer From the Korea Central Cancer Registry
por: Park, Hyoung-Chul, et al.
Publicado: (2013)

CTCF controls three-dimensional enhancer network underlying the inflammatory response of bone marrow-derived dendritic cells
por: Yang, Bobae, et al.
Publicado: (2023)

Combination of oxaliplatin, fluorouracil, and leucovorin in the treatment of fluoropyrimidine-pretreated patients with metastatic colorectal cancer.
por: Lee, J. H., et al.
Publicado: (2001)

β-Lapachone Exerts Anticancer Effects by Downregulating p53, Lys-Acetylated Proteins, TrkA, p38 MAPK, SOD1, Caspase-2, CD44 and NPM in Oxaliplatin-Resistant HCT116 Colorectal Cancer Cells
por: Jung, Eun Joo, et al.
Publicado: (2023)

Exposure to Cigarette Smoke Contributes to the Risk of Developing a Colorectal Adenoma, Doesn't It? Are Repeated Exposures to Such Smoke Dangerous?
por: Lee, Bong Hwa, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_g0jkevcgm005uee9flpjhcali2