An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus enters host cells via an interaction between its Spike protein and the host cell receptor angiotensin-converting enzyme 2 (ACE2). By screening a yeast surface-displayed library of synthetic nanobody sequences, we developed nanobo...

Descripción completa

Detalles Bibliográficos
Autores principales: Schoof, Michael, Faust, Bryan, Saunders, Reuben A., Sangwan, Smriti, Rezelj, Veronica, Hoppe, Nick, Boone, Morgane, Billesbølle, Christian B., Puchades, Cristina, Azumaya, Caleigh M., Kratochvil, Huong T., Zimanyi, Marcell, Deshpande, Ishan, Liang, Jiahao, Dickinson, Sasha, Nguyen, Henry C., Chio, Cynthia M., Merz, Gregory E., Thompson, Michael C., Diwanji, Devan, Schaefer, Kaitlin, Anand, Aditya A., Dobzinski, Niv, Zha, Beth Shoshana, Simoneau, Camille R., Leon, Kristoffer, White, Kris M., Chio, Un Seng, Gupta, Meghna, Jin, Mingliang, Li, Fei, Liu, Yanxin, Zhang, Kaihua, Bulkley, David, Sun, Ming, Smith, Amber M., Rizo, Alexandrea N., Moss, Frank, Brilot, Axel F., Pourmal, Sergei, Trenker, Raphael, Pospiech, Thomas, Gupta, Sayan, Barsi-Rhyne, Benjamin, Belyy, Vladislav, Barile-Hill, Andrew W., Nock, Silke, Liu, Yuwei, Krogan, Nevan J., Ralston, Corie Y., Swaney, Danielle L., García-Sastre, Adolfo, Ott, Melanie, Vignuzzi, Marco, Walter, Peter, Manglik, Aashish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857409/
https://www.ncbi.nlm.nih.gov/pubmed/33154106
http://dx.doi.org/10.1126/science.abe3255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857409/
https://www.ncbi.nlm.nih.gov/pubmed/33154106
http://dx.doi.org/10.1126/science.abe3255

Ejemplares similares