Conformational dynamics during high-fidelity DNA replication and translocation defined using a DNA polymerase with a fluorescent artificial amino acid

We address the role of enzyme conformational dynamics in specificity for a high-fidelity DNA polymerase responsible for genome replication. We present the complete characterization of the conformational dynamics during the correct nucleotide incorporation forward and reverse reactions using stopped-...

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Detalles Bibliográficos
Autores principales: Dangerfield, Tyler L., Johnson, Kenneth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857513/
https://www.ncbi.nlm.nih.gov/pubmed/33273013
http://dx.doi.org/10.1074/jbc.RA120.016617

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857513/
https://www.ncbi.nlm.nih.gov/pubmed/33273013
http://dx.doi.org/10.1074/jbc.RA120.016617

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