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Conformational dynamics during high-fidelity DNA replication and translocation defined using a DNA polymerase with a fluorescent artificial amino acid

We address the role of enzyme conformational dynamics in specificity for a high-fidelity DNA polymerase responsible for genome replication. We present the complete characterization of the conformational dynamics during the correct nucleotide incorporation forward and reverse reactions using stopped-...

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Detalles Bibliográficos
Autores principales:	Dangerfield, Tyler L., Johnson, Kenneth A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857513/ https://www.ncbi.nlm.nih.gov/pubmed/33273013 http://dx.doi.org/10.1074/jbc.RA120.016617

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