Seipin traps triacylglycerols to facilitate their nanoscale clustering in the endoplasmic reticulum membrane

Seipin is a disk-like oligomeric endoplasmic reticulum (ER) protein important for lipid droplet (LD) biogenesis and triacylglycerol (TAG) delivery to growing LDs. Here we show through biomolecular simulations bridged to experiments that seipin can trap TAGs in the ER bilayer via the luminal hydropho...

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Detalles Bibliográficos
Autores principales: Prasanna, Xavier, Salo, Veijo T., Li, Shiqian, Ven, Katharina, Vihinen, Helena, Jokitalo, Eija, Vattulainen, Ilpo, Ikonen, Elina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857593/
https://www.ncbi.nlm.nih.gov/pubmed/33481779
http://dx.doi.org/10.1371/journal.pbio.3000998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857593/
https://www.ncbi.nlm.nih.gov/pubmed/33481779
http://dx.doi.org/10.1371/journal.pbio.3000998

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