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Seipin traps triacylglycerols to facilitate their nanoscale clustering in the endoplasmic reticulum membrane
Seipin is a disk-like oligomeric endoplasmic reticulum (ER) protein important for lipid droplet (LD) biogenesis and triacylglycerol (TAG) delivery to growing LDs. Here we show through biomolecular simulations bridged to experiments that seipin can trap TAGs in the ER bilayer via the luminal hydropho...
Autores principales: | Prasanna, Xavier, Salo, Veijo T., Li, Shiqian, Ven, Katharina, Vihinen, Helena, Jokitalo, Eija, Vattulainen, Ilpo, Ikonen, Elina |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857593/ https://www.ncbi.nlm.nih.gov/pubmed/33481779 http://dx.doi.org/10.1371/journal.pbio.3000998 |
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