Multicomponent reaction–derived covalent inhibitor space

The area of covalent inhibitors is gaining momentum due to recently introduced clinical drugs, but libraries of these compounds are scarce. Multicomponent reaction (MCR) chemistry is well known for its easy access to a very large and diverse chemical space. Here, we show that MCRs are highly suitabl...

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Detalles Bibliográficos
Autores principales: Sutanto, Fandi, Shaabani, Shabnam, Neochoritis, Constantinos G., Zarganes-Tzitzikas, Tryfon, Patil, Pravin, Ghonchepour, Ehsan, Dömling, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857676/
https://www.ncbi.nlm.nih.gov/pubmed/33536213
http://dx.doi.org/10.1126/sciadv.abd9307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857676/
https://www.ncbi.nlm.nih.gov/pubmed/33536213
http://dx.doi.org/10.1126/sciadv.abd9307

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