Cargando…

Primary Cilia as a Biomarker in Mesenchymal Stem Cells Senescence: Influencing Osteoblastic Differentiation Potency Associated with Hedgehog Signaling Regulation

Bone tissue engineering-based therapy for bone lesions requires the expansion of seeding cells, such as autologous mesenchymal stem cells (MSCs). A major obstacle to this process is the loss of the phenotype and differentiation capacity of MSCs subjected to passage. Recent studies have suggested tha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fu, Su, Zhang, Chunlin, Yan, Xu, Li, Dongzhe, Wang, Yongkui, Dong, Chao, Cao, Zhengming, Ning, Yongming, Shao, Chenglong, Yang, Tengyue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857927/ https://www.ncbi.nlm.nih.gov/pubmed/33574852 http://dx.doi.org/10.1155/2021/8850114

Ejemplares similares

Cervical microendoscopic laminoplasty-induced clinical resolution of disc herniation in patients with single- to three-level myelopathy
por: Zhang, Chunlin, et al.
Publicado: (2022)

Vertebrate Hedgehog signaling: cilia rule
por: Wilson, Christopher W, et al.
Publicado: (2010)

Control of Hedgehog Signalling by the Cilia-Regulated Proteasome
por: Gerhardt, Christoph, et al.
Publicado: (2016)

Primary cilia attenuate hedgehog signalling in neoplastic chondrocytes
por: Ho, L, et al.
Publicado: (2013)

Primary cilia as the nexus of biophysical and hedgehog signaling at the tendon enthesis
por: Fang, Fei, et al.
Publicado: (2020)

Motile cilia of human airway epithelia contain hedgehog signaling components that mediate noncanonical hedgehog signaling
por: Mao, Suifang, et al.
Publicado: (2018)

Cilia-mediated Hedgehog signaling controls form and function in the mammalian larynx
por: Tabler, Jacqueline M, et al.
Publicado: (2017)

Cilia-related protein SPEF2 regulates osteoblast differentiation
por: Lehti, Mari S., et al.
Publicado: (2018)

Hedgehog pathway responsiveness correlates with the presence of primary cilia on prostate stromal cells
por: Zhang, Jingxian, et al.
Publicado: (2009)

Motional dynamics of single Patched1 molecules in cilia are controlled by Hedgehog and cholesterol
por: Weiss, Lucien E., et al.
Publicado: (2019)

Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals
por: Findakly, Sarah, et al.
Publicado: (2020)

Systematic analysis of cilia characteristics and Hedgehog signaling in five immortal cell lines
por: Gómez, Arianna Ericka, et al.
Publicado: (2022)

Mechanism of Methylprednisolone‐Induced Primary Cilia Formation Disorder and Autophagy in Osteoblasts
por: Zhao, Zhen‐qun, et al.
Publicado: (2020)

Characterization of Primary Cilia in Osteoblasts Isolated From Patients With ADPKD and CKD
por: Pereira, Renata C, et al.
Publicado: (2021)

Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery
por: Kiprilov, Enko N., et al.
Publicado: (2008)

Mechanical strain disrupts primary cilia structure and modulates hedgehog signalling in adult chondrocytes
por: Thompson, CL, et al.
Publicado: (2012)

A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation
por: Jiang, Shiyou, et al.
Publicado: (2015)

Amyloid-β interrupts canonical Sonic hedgehog signaling by distorting primary cilia structure
por: Vorobyeva, Anna G., et al.
Publicado: (2018)

ARL13B regulates Sonic hedgehog signaling from outside primary cilia
por: Gigante, Eduardo D, et al.
Publicado: (2020)

SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts
por: Sun, Jun, et al.
Publicado: (2021)

Microgravity induces inhibition of osteoblastic differentiation and mineralization through abrogating primary cilia
por: Shi, Wengui, et al.
Publicado: (2017)

Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus
por: Blair, Helen J, et al.
Publicado: (2011)

Mutations in OSBPL2 cause hearing loss associated with primary cilia defects via sonic hedgehog signaling
por: Shi, Hairong, et al.
Publicado: (2022)

Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation
por: Yuan, Xue, et al.
Publicado: (2016)

Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain
por: Khan, Shahzad S, et al.
Publicado: (2021)

Activation of Cilia-Independent Hedgehog/GLI1 Signaling as a Novel Concept for Neuroblastoma Therapy
por: Koeniger, Anke, et al.
Publicado: (2021)

Hedgehog Signaling in Tumor Cells Facilitates Osteoblast-Enhanced Osteolytic Metastases
por: Das, Shamik, et al.
Publicado: (2012)

The value of the hedgehog signal in osteoblasts in fluoride-induced bone-tissue injury
por: Deng, Chaonan, et al.
Publicado: (2021)

Osteoblast-secreted collagen upregulates paracrine Sonic hedgehog signaling by prostate cancer cells and enhances osteoblast differentiation
por: Zunich, Samantha M, et al.
Publicado: (2012)

Astragaloside IV promotes the proliferation and migration of osteoblast-like cells through the hedgehog signaling pathway
por: Guo, Li-Hua, et al.
Publicado: (2019)

Extracellular Vesicles from Adipose-Derived Mesenchymal Stem Cells Downregulate Senescence Features in Osteoarthritic Osteoblasts
por: Tofiño-Vian, Miguel, et al.
Publicado: (2017)

A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes
por: Tukachinsky, Hanna, et al.
Publicado: (2010)

The Kinesin-4 Protein KIF7 Regulates Mammalian Hedgehog Signaling by Organizing the Cilia Tip Compartment
por: He, Mu, et al.
Publicado: (2014)

Activation of the G(i) protein-RHOA axis by non-canonical Hedgehog signaling is independent of primary cilia
por: Ho Wei, Lan, et al.
Publicado: (2018)

TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms
por: Rosengren, Thomas, et al.
Publicado: (2018)

A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling
por: Frikstad, Kari-Anne M., et al.
Publicado: (2019)

Etoposide Triggers Cellular Senescence by Inducing Multiple Centrosomes and Primary Cilia in Adrenocortical Tumor Cells
por: Teng, Yen-Ni, et al.
Publicado: (2021)

Primary cilia respond to fluid shear stress and mediate flow-induced calcium deposition in osteoblasts
por: Delaine-Smith, Robin M., et al.
Publicado: (2014)

Protection of primary cilia is an effective countermeasure against the impairment of osteoblast function induced by simulated microgravity
por: Liu, Jing, et al.
Publicado: (2022)

Paracrine sonic hedgehog signalling by prostate cancer cells induces osteoblast differentiation
por: Zunich, Samantha M, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_911g04kple0b2g7s55tknj8n68