Sphingomyelin Biosynthesis Is Essential for Phagocytic Signaling during Mycobacterium tuberculosis Host Cell Entry

Phagocytosis by alveolar macrophages is the obligate first step in Mycobacterium tuberculosis (Mtb) infection, yet the mechanism underlying this process is incompletely understood. Here, we show that Mtb invasion relies on an intact sphingolipid biosynthetic pathway. Inhibition or knockout of early...

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Detalles Bibliográficos
Autores principales: Niekamp, Patrick, Guzman, Gaelen, Leier, Hans C., Rashidfarrokhi, Ali, Richina, Veronica, Pott, Fabian, Barisch, Caroline, Holthuis, Joost C. M., Tafesse, Fikadu G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7858061/
https://www.ncbi.nlm.nih.gov/pubmed/33500344
http://dx.doi.org/10.1128/mBio.03141-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7858061/
https://www.ncbi.nlm.nih.gov/pubmed/33500344
http://dx.doi.org/10.1128/mBio.03141-20

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