Downregulation of miR‐326 and its host gene β‐arrestin1 induces pro‐survival activity of E2F1 and promotes medulloblastoma growth

Persistent mortality rates of medulloblastoma (MB) and severe side effects of the current therapies require the definition of the molecular mechanisms that contribute to tumor progression. Using cultured MB cancer stem cells and xenograft tumors generated in mice, we show that low expression of miR‐...

Descripción completa

Detalles Bibliográficos
Autores principales: Miele, Evelina, Po, Agnese, Mastronuzzi, Angela, Carai, Andrea, Besharat, Zein Mersini, Pediconi, Natalia, Abballe, Luana, Catanzaro, Giuseppina, Sabato, Claudia, De Smaele, Enrico, Canettieri, Gianluca, Di Marcotullio, Lucia, Vacca, Alessandra, Mai, Antonello, Levrero, Massimo, Pfister, Stefan M., Kool, Marcel, Giangaspero, Felice, Locatelli, Franco, Ferretti, Elisabetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7858128/
https://www.ncbi.nlm.nih.gov/pubmed/32920979
http://dx.doi.org/10.1002/1878-0261.12800

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7858128/
https://www.ncbi.nlm.nih.gov/pubmed/32920979
http://dx.doi.org/10.1002/1878-0261.12800

Ejemplares similares