Specific inhibition of FGF5-induced cell proliferation by RNA aptamers

Fibroblast growth factor 5 (FGF5) is a crucial regulator of hair growth and an oncogenic factor in several human cancers. To generate FGF5 inhibitors, we performed Systematic Evolution of Ligands by EXponential enrichment and obtained novel RNA aptamers that have high affinity to human FGF5. These a...

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Detalles Bibliográficos
Autores principales: Amano, Ryo, Namekata, Masato, Horiuchi, Masataka, Saso, Minami, Yanagisawa, Takuya, Tanaka, Yoichiro, Ghani, Farhana Ishrat, Yamamoto, Masakuni, Sakamoto, Taiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7858594/
https://www.ncbi.nlm.nih.gov/pubmed/33536494
http://dx.doi.org/10.1038/s41598-021-82350-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7858594/
https://www.ncbi.nlm.nih.gov/pubmed/33536494
http://dx.doi.org/10.1038/s41598-021-82350-w

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