Activation of the Nlrp3 Inflammasome Contributes to Shiga Toxin-Induced Hemolytic Uremic Syndrome in a Mouse Model

OBJECTIVE: To explore the role of the Nlrp3 inflammasome activation in the development of hemolytic uremic syndrome (HUS) induced by Stx2 and evaluate the efficacy of small molecule Nlrp3 inhibitors in preventing the HUS. METHODS: Peritoneal macrophages (PMs) isolated from wild-type (WT) C57BL/6J mi...

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Detalles Bibliográficos
Autores principales: Song, Liqiong, Xiao, Yuchun, Li, Xianping, Huang, Yuanming, Meng, Guangxun, Ren, Zhihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859089/
https://www.ncbi.nlm.nih.gov/pubmed/33552083
http://dx.doi.org/10.3389/fimmu.2020.619096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859089/
https://www.ncbi.nlm.nih.gov/pubmed/33552083
http://dx.doi.org/10.3389/fimmu.2020.619096

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