Eomes Impedes Durable Response to Tumor Immunotherapy by Inhibiting Stemness, Tissue Residency, and Promoting the Dysfunctional State of Intratumoral CD8(+) T Cells

Sustaining efficacious T cell-mediated antitumor immune responses in the tumor tissues is the key to the success of cancer immunotherapy. Current strategies leverage altering the signals T cells sense in the tumor microenvironment (TME). Checkpoint inhibitor-based approaches block inhibitory signals...

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Detalles Bibliográficos
Autores principales: Sun, Runzi, Wu, Yixian, Zhou, Huijun, Wu, Yanshi, Yang, Zhongzhou, Gu, Yanzheng, Jiang, Jingting, Lu, Binfeng, Zhu, Yibei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859102/
https://www.ncbi.nlm.nih.gov/pubmed/33553191
http://dx.doi.org/10.3389/fcell.2021.640224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859102/
https://www.ncbi.nlm.nih.gov/pubmed/33553191
http://dx.doi.org/10.3389/fcell.2021.640224

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