Conserved arginine residues in synaptotagmin 1 regulate fusion pore expansion through membrane contact

Synaptotagmin 1 is a vesicle-anchored membrane protein that functions as the Ca(2+) sensor for synchronous neurotransmitter release. In this work, an arginine containing region in the second C2 domain of synaptotagmin 1 (C2B) is shown to control the expansion of the fusion pore and thereby the conce...

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Detalles Bibliográficos
Autores principales: Nyenhuis, Sarah B., Karandikar, Nakul, Kiessling, Volker, Kreutzberger, Alex J. B., Thapa, Anusa, Liang, Binyong, Tamm, Lukas K., Cafiso, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859215/
https://www.ncbi.nlm.nih.gov/pubmed/33536412
http://dx.doi.org/10.1038/s41467-021-21090-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859215/
https://www.ncbi.nlm.nih.gov/pubmed/33536412
http://dx.doi.org/10.1038/s41467-021-21090-x

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