Discovery of Diaryl Ether Substituted Tetrahydrophthalazinones as TbrPDEB1 Inhibitors Following Structure-Based Virtual Screening

Several members of the 3′,5′-cyclic nucleotide phosphodiesterase (PDE) family play an essential role in cellular processes, which has labeled them as interesting targets for various diseases. The parasitic protozoan Trypanosoma brucei, causative agent of human African trypanosomiasis, contains sever...

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Detalles Bibliográficos
Autores principales: de Heuvel, Erik, Kooistra, Albert J., Edink, Ewald, van Klaveren, Sjors, Stuijt, Jeffrey, van der Meer, Tiffany, Sadek, Payman, Mabille, Dorien, Caljon, Guy, Maes, Louis, Siderius, Marco, de Esch, Iwan J. P., Sterk, Geert Jan, Leurs, Rob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859335/
https://www.ncbi.nlm.nih.gov/pubmed/33553105
http://dx.doi.org/10.3389/fchem.2020.608030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859335/
https://www.ncbi.nlm.nih.gov/pubmed/33553105
http://dx.doi.org/10.3389/fchem.2020.608030

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