Both Hypoxia-Inducible Factor 1 and MAPK Signaling Pathway Attenuate PI3K/AKT via Suppression of Reactive Oxygen Species in Human Pluripotent Stem Cells

Mild hypoxia (5% O(2)) as well as FGFR1-induced activation of phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B (PI3K/AKT) and MAPK signaling pathways markedly support pluripotency in human pluripotent stem cells (hPSCs). This study demonstrates that the pluripotency-promoting PI3K/AKT...

Descripción completa

Detalles Bibliográficos
Autores principales: Fojtík, Petr, Beckerová, Deborah, Holomková, Katerina, Šenfluk, Martin, Rotrekl, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859355/
https://www.ncbi.nlm.nih.gov/pubmed/33553145
http://dx.doi.org/10.3389/fcell.2020.607444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859355/
https://www.ncbi.nlm.nih.gov/pubmed/33553145
http://dx.doi.org/10.3389/fcell.2020.607444

Ejemplares similares