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Shear Stress Rescued the Neuronal Impairment Induced by Global Cerebral Ischemia Reperfusion via Activating PECAM-1-eNOS-NO Pathway

Microvessel hypoperfusion following ischemic stress resulted in a decreased shear stress of brain microvascular endothelial cells (BMECs) and contributed to abnormal expression of PECAM-1 after global cerebral ischemia/reperfusion (I/R) injury. Here, we identified novel pathophysiologic and rehabili...

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Autores principales: Gao, Jing-Quan, Wang, Peng, Yan, Jun-Wei, Ba, Li-Na, Shi, Pi-Long, Wu, Hong-Mei, Guan, Xue-Ying, Cao, Yong-gang, Sun, Hong-Li, Mao, Xiao-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859356/
https://www.ncbi.nlm.nih.gov/pubmed/33553171
http://dx.doi.org/10.3389/fcell.2020.631286
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author Gao, Jing-Quan
Wang, Peng
Yan, Jun-Wei
Ba, Li-Na
Shi, Pi-Long
Wu, Hong-Mei
Guan, Xue-Ying
Cao, Yong-gang
Sun, Hong-Li
Mao, Xiao-Yuan
author_facet Gao, Jing-Quan
Wang, Peng
Yan, Jun-Wei
Ba, Li-Na
Shi, Pi-Long
Wu, Hong-Mei
Guan, Xue-Ying
Cao, Yong-gang
Sun, Hong-Li
Mao, Xiao-Yuan
author_sort Gao, Jing-Quan
collection PubMed
description Microvessel hypoperfusion following ischemic stress resulted in a decreased shear stress of brain microvascular endothelial cells (BMECs) and contributed to abnormal expression of PECAM-1 after global cerebral ischemia/reperfusion (I/R) injury. Here, we identified novel pathophysiologic and rehabilitative procedures specific to shear stress in microvascular endothelial cells in response to global cerebral I/R injury. We found that the decrease in cerebral blood flow of gerbils after global cerebral I/R injury reduces shear stress, and the abnormal change in shear stress leads to microvascular endothelial cell and neuron damage. Nevertheless, suitable high levels of shear stress contribute to rescuing the dysfunction and malformation of BMECs via regulating the PECAM-1-eNOS-NO pathway to enhance nitric oxide release, decrease the expression of caspase-3 to reduce apoptosis, and improve the shear-adaptability of endothelial cells, thereby playing a protective role in the gerbil brain.
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spelling pubmed-78593562021-02-05 Shear Stress Rescued the Neuronal Impairment Induced by Global Cerebral Ischemia Reperfusion via Activating PECAM-1-eNOS-NO Pathway Gao, Jing-Quan Wang, Peng Yan, Jun-Wei Ba, Li-Na Shi, Pi-Long Wu, Hong-Mei Guan, Xue-Ying Cao, Yong-gang Sun, Hong-Li Mao, Xiao-Yuan Front Cell Dev Biol Cell and Developmental Biology Microvessel hypoperfusion following ischemic stress resulted in a decreased shear stress of brain microvascular endothelial cells (BMECs) and contributed to abnormal expression of PECAM-1 after global cerebral ischemia/reperfusion (I/R) injury. Here, we identified novel pathophysiologic and rehabilitative procedures specific to shear stress in microvascular endothelial cells in response to global cerebral I/R injury. We found that the decrease in cerebral blood flow of gerbils after global cerebral I/R injury reduces shear stress, and the abnormal change in shear stress leads to microvascular endothelial cell and neuron damage. Nevertheless, suitable high levels of shear stress contribute to rescuing the dysfunction and malformation of BMECs via regulating the PECAM-1-eNOS-NO pathway to enhance nitric oxide release, decrease the expression of caspase-3 to reduce apoptosis, and improve the shear-adaptability of endothelial cells, thereby playing a protective role in the gerbil brain. Frontiers Media S.A. 2021-01-21 /pmc/articles/PMC7859356/ /pubmed/33553171 http://dx.doi.org/10.3389/fcell.2020.631286 Text en Copyright © 2021 Gao, Wang, Yan, Ba, Shi, Wu, Guan, Cao, Sun and Mao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Gao, Jing-Quan
Wang, Peng
Yan, Jun-Wei
Ba, Li-Na
Shi, Pi-Long
Wu, Hong-Mei
Guan, Xue-Ying
Cao, Yong-gang
Sun, Hong-Li
Mao, Xiao-Yuan
Shear Stress Rescued the Neuronal Impairment Induced by Global Cerebral Ischemia Reperfusion via Activating PECAM-1-eNOS-NO Pathway
title Shear Stress Rescued the Neuronal Impairment Induced by Global Cerebral Ischemia Reperfusion via Activating PECAM-1-eNOS-NO Pathway
title_full Shear Stress Rescued the Neuronal Impairment Induced by Global Cerebral Ischemia Reperfusion via Activating PECAM-1-eNOS-NO Pathway
title_fullStr Shear Stress Rescued the Neuronal Impairment Induced by Global Cerebral Ischemia Reperfusion via Activating PECAM-1-eNOS-NO Pathway
title_full_unstemmed Shear Stress Rescued the Neuronal Impairment Induced by Global Cerebral Ischemia Reperfusion via Activating PECAM-1-eNOS-NO Pathway
title_short Shear Stress Rescued the Neuronal Impairment Induced by Global Cerebral Ischemia Reperfusion via Activating PECAM-1-eNOS-NO Pathway
title_sort shear stress rescued the neuronal impairment induced by global cerebral ischemia reperfusion via activating pecam-1-enos-no pathway
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859356/
https://www.ncbi.nlm.nih.gov/pubmed/33553171
http://dx.doi.org/10.3389/fcell.2020.631286
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