A Dimerization Site at SCR-17/18 in Factor H Clarifies a New Mechanism for Complement Regulatory Control

Complement Factor H (CFH), with 20 short complement regulator (SCR) domains, regulates the alternative pathway of complement in part through the interaction of its C-terminal SCR-19 and SCR-20 domains with host cell-bound C3b and anionic oligosaccharides. In solution, CFH forms small amounts of olig...

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Detalles Bibliográficos
Autores principales: Dunne, Orla M., Gao, Xin, Nan, Ruodan, Gor, Jayesh, Adamson, Penelope J., Gordon, David L., Moulin, Martine, Haertlein, Michael, Forsyth, V. Trevor, Perkins, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859452/
https://www.ncbi.nlm.nih.gov/pubmed/33552059
http://dx.doi.org/10.3389/fimmu.2020.601895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859452/
https://www.ncbi.nlm.nih.gov/pubmed/33552059
http://dx.doi.org/10.3389/fimmu.2020.601895

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