Cargando…

A Dimerization Site at SCR-17/18 in Factor H Clarifies a New Mechanism for Complement Regulatory Control

Complement Factor H (CFH), with 20 short complement regulator (SCR) domains, regulates the alternative pathway of complement in part through the interaction of its C-terminal SCR-19 and SCR-20 domains with host cell-bound C3b and anionic oligosaccharides. In solution, CFH forms small amounts of olig...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dunne, Orla M., Gao, Xin, Nan, Ruodan, Gor, Jayesh, Adamson, Penelope J., Gordon, David L., Moulin, Martine, Haertlein, Michael, Forsyth, V. Trevor, Perkins, Stephen J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859452/ https://www.ncbi.nlm.nih.gov/pubmed/33552059 http://dx.doi.org/10.3389/fimmu.2020.601895

Ejemplares similares

Zinc-induced Self-association of Complement C3b and Factor H: IMPLICATIONS FOR INFLAMMATION AND AGE-RELATED MACULAR DEGENERATION
por: Nan, Ruodan, et al.
Publicado: (2013)

Zinc Binding to the Tyr402 and His402 Allotypes of Complement Factor H: Possible Implications for Age-Related Macular Degeneration
por: Nan, Ruodan, et al.
Publicado: (2011)

Matchout deuterium labelling of proteins for small-angle neutron scattering studies using prokaryotic and eukaryotic expression systems and high cell-density cultures
por: Dunne, O., et al.
Publicado: (2016)

A Revised Mechanism for the Activation of Complement C3 to C3b: A MOLECULAR EXPLANATION OF A DISEASE-ASSOCIATED POLYMORPHISM
por: Rodriguez, Elizabeth, et al.
Publicado: (2015)

Two distinct conformations of factor H regulate discrete complement-binding functions in the fluid phase and at cell surfaces
por: Osborne, Amy J., et al.
Publicado: (2018)

Back-exchange of deuterium in neutron crystallography: characterization by IR spectroscopy
por: Yee, Ai Woon, et al.
Publicado: (2017)

The Concave Face of Decorin Mediates Reversible Dimerization and Collagen Binding
por: Islam, Mehwaesh, et al.
Publicado: (2013)

Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation
por: Nan, Ruodan, et al.
Publicado: (2017)

Near-planar Solution Structures of Mannose-binding Lectin Oligomers Provide Insight on Activation of Lectin Pathway of Complement
por: Miller, Ami, et al.
Publicado: (2012)

SCR manual
por: Gutzwiller, F W
Publicado: (1967)

Non-linearity of the collagen triple helix in solution and implications for collagen function
por: Walker, Kenneth T., et al.
Publicado: (2017)

Impact of Deuteration on the Assembly Kinetics of Transthyretin Monitored by Native Mass Spectrometry and Implications for Amyloidoses
por: Yee, Ai Woon, et al.
Publicado: (2016)

SARS-CoV-2 spike protein removes lipids from model membranes and interferes with the capacity of high density lipoprotein to exchange lipids
por: Correa, Yubexi, et al.
Publicado: (2021)

The Production of Matchout-Deuterated Cholesterol and the Study of Bilayer-Cholesterol Interactions
por: Waldie, Sarah, et al.
Publicado: (2019)

Fast SCR Thyratron Driver
por: Nguyen, M N, et al.
Publicado: (1991)

A solution structure analysis reveals a bent collagen triple helix in the complement activation recognition molecule mannan-binding lectin
por: Iqbal, Hina, et al.
Publicado: (2022)

Water Dynamics in Shewanella oneidensis at Ambient and High Pressure using Quasi-Elastic Neutron Scattering
por: Foglia, Fabrizia, et al.
Publicado: (2016)

Structural basis for activation of plasma-membrane Ca(2+)-ATPase by calmodulin
por: Nitsche, Julius, et al.
Publicado: (2018)

SCR-22 of pollen-dominant S haplotype class is recessive to SCR-44 of pollen-recessive S haplotype class in Brassica rapa
por: Wang, Chun-Lei, et al.
Publicado: (2019)

SCR manual: including triacs and other thyristors
por: Grafham, D R, et al.
Publicado: (1979)

Hydrothermal Aging Mechanism and Modeling for SCR Catalysts
por: Yao, Dongwei, et al.
Publicado: (2023)

Sensitive and specific assays for C3 nephritic factors clarify mechanisms underlying complement dysregulation
por: Paixão-Cavalcante, Danielle, et al.
Publicado: (2012)

The XRE-DUF397 Protein Pair, Scr1 and Scr2, Acts as a Strong Positive Regulator of Antibiotic Production in Streptomyces
por: Santamaría, Ramón I., et al.
Publicado: (2018)

In Vivo Water Dynamics in Shewanella oneidensis Bacteria at High Pressure
por: Foglia, Fabrizia, et al.
Publicado: (2019)

Identification of the mechanism of NO reduction with ammonia (SCR) on zeolite catalysts
por: Khivantsev, Konstantin, et al.
Publicado: (2022)

ESD Research of SCR Devices under Harsh Environments
por: Lin, Chien-Chun, et al.
Publicado: (2023)

Clarifying Water
Publicado: (1867)

Clarifying Water
Publicado: (1879)

Electrostatic Interactions between Complement Regulator CD46(SCR1-2) and Adenovirus Ad11/Ad21 Fiber Protein Knob
por: Chen, Carl Z., et al.
Publicado: (2015)

Single-Molecule Imaging and Computational Microscopy Approaches Clarify the Mechanism of the Dimerization and Membrane Interactions of Green Fluorescent Protein
por: Wang, Xiaohua, et al.
Publicado: (2019)

Dimerization of ABCG2 Analysed by Bimolecular Fluorescence Complementation
por: Haider, Ameena J., et al.
Publicado: (2011)

Evaluation of the RF SCR Cabinet Design and Proposed Solution Philosophy
por: Markovich, G M
Publicado: (1997)

Clarifying the quantum mechanical origin of the covalent chemical bond
por: Levine, Daniel S., et al.
Publicado: (2020)

Time-resolved small-angle neutron scattering as a probe for the dynamics of lipid exchange between human lipoproteins and naturally derived membranes
por: Maric, Selma, et al.
Publicado: (2019)

Photonics tools begin to clarify astrocyte calcium transients
por: Gorzo, Kelsea A., et al.
Publicado: (2022)

Clarifying the Mechanisms of Antidepressants
por: Tucker, Don M.
Publicado: (2015)

Clarifying the origin of Houzao
por: Zhao, Zhongzhen, et al.
Publicado: (2018)

Formation and Characterization of Supported Lipid Bilayers Composed of Hydrogenated and Deuterated Escherichia coli Lipids
por: Lind, Tania Kjellerup, et al.
Publicado: (2015)

Elongation rate and average length of amyloid fibrils in solution using isotope-labelled small-angle neutron scattering
por: Eves, Ben J., et al.
Publicado: (2021)

Neutron crystallography reveals mechanisms used by Pseudomonas aeruginosa for host-cell binding
por: Gajdos, Lukas, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_tb6nlejih9lu7cvjbuk5adq6t2