Intracolonic Mustard Oil Induces Visceral Pain in Mice by TRPA1-Dependent and -Independent Mechanisms: Role of Tissue Injury and P2X Receptors

Both TRPA1 and purinergic P2X receptors have been proposed as potential targets for the treatment of visceral pain. We found that the intracolonic administration of a low dose mustard oil (0.5%), a well-known TRPA1 agonist, produced nociceptive responses and abdominal wall referred mechanical hypera...

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Detalles Bibliográficos
Autores principales: Gonzalez-Cano, Rafael, Montilla-García, Ángeles, Perazzoli, Gloria, Torres, Jesús M., Cañizares, Francisco J., Fernández-Segura, Eduardo, Costigan, Michael, Baeyens, José M., Cobos, Enrique J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859884/
https://www.ncbi.nlm.nih.gov/pubmed/33551815
http://dx.doi.org/10.3389/fphar.2020.613068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859884/
https://www.ncbi.nlm.nih.gov/pubmed/33551815
http://dx.doi.org/10.3389/fphar.2020.613068

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