DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks

The present study demonstrates that topoisomerase 3B (TOP3B) forms both RNA and DNA cleavage complexes (TOP3Bccs) in vivo and reveals a pathway for repairing TOP3Bccs. For inducing and detecting cellular TOP3Bccs, we engineer a “self-trapping” mutant of TOP3B (R338W-TOP3B). Transfection with R338W-T...

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Detalles Bibliográficos
Autores principales: Saha, Sourav, Sun, Yilun, Naomi Huang, Shar-yin, Baechler, Simone Andrea, Pongor, Lorinc Sandor, Agama, Keli, Jo, Ukhyun, Zhang, Hongliang, Tse-Dinh, Yuk-Ching, Pommier, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859927/
https://www.ncbi.nlm.nih.gov/pubmed/33378676
http://dx.doi.org/10.1016/j.celrep.2020.108569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859927/
https://www.ncbi.nlm.nih.gov/pubmed/33378676
http://dx.doi.org/10.1016/j.celrep.2020.108569

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