In vitro and ex vivo anti-tumor effect and mechanism of Tucatinib in leukemia stem cells and ABCG2-overexpressing leukemia cells

Leukemia stem cells (LSCs), which evade standard chemotherapy, may lead to chemoresistance and disease relapse. The overexpression of ATP-binding cassette subfamily G member 2 (ABCG2) is an important determinant of drug resistance in LSCs and it can serve as a marker for LSCs. Targeting ABCG2 is a p...

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Detalles Bibliográficos
Autores principales: Jing, Wen, Zhou, Mao, Chen, Ruixia, Ye, Xijiu, Li, Weixing, Su, Xiangfei, Luo, Jianwei, Wang, Zhi, Peng, Shuling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859976/
https://www.ncbi.nlm.nih.gov/pubmed/33650639
http://dx.doi.org/10.3892/or.2020.7915

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859976/
https://www.ncbi.nlm.nih.gov/pubmed/33650639
http://dx.doi.org/10.3892/or.2020.7915

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