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GLI2 but not GLI1/GLI3 plays a central role in the induction of malignant phenotype of gallbladder cancer

We previously reported that Hedgehog (Hh) signal was enhanced in gallbladder cancer (GBC) and was involved in the induction of malignant phenotype of GBC. In recent years, therapeutics that target Hh signaling have focused on molecules downstream of smoothened (SMO). The three transcription factors...

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Detalles Bibliográficos
Autores principales: Ichimiya, Shu, Onishi, Hideya, Nagao, Shinjiro, Koga, Satoko, Sakihama, Kukiko, Nakayama, Kazunori, Fujimura, Akiko, Oyama, Yasuhiro, Imaizumi, Akira, Oda, Yoshinao, Nakamura, Masafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7860001/
https://www.ncbi.nlm.nih.gov/pubmed/33650666
http://dx.doi.org/10.3892/or.2021.7947