Influence of the pK(a) Value of Cinnamic Acid and P-Hydroxycinnamic Acid on the Solubility of a Lurasidone Hydrochloride-Based Coamorphous System

[Image: see text] Coamorphization of a poorly water-soluble active pharmaceutical ingredient (API) has been proven to be effective in improving its solubility. Generally, API can form multiple coamorphous systems with different coformers. However, it remains unclear how the pK(a) value of different...

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Detalles Bibliográficos
Autores principales: Hu, Yi, Guo, Yujie, Li, Bin, Xu, Renjie, Fang, Xiaoping, Cao, Yan, Liu, Zifan, Jiang, Cuiping, Lu, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7860058/
https://www.ncbi.nlm.nih.gov/pubmed/33553927
http://dx.doi.org/10.1021/acsomega.0c05510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7860058/
https://www.ncbi.nlm.nih.gov/pubmed/33553927
http://dx.doi.org/10.1021/acsomega.0c05510

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