Cargando…

The ubiquinone synthesis pathway is a promising drug target for Chagas disease

Chagas disease is caused by infection with the protozoan parasite Trypanosoma cruzi (T. cruzi). It was originally a Latin American endemic health problem, but now is expanding worldwide as a result of increasing migration. The currently available drugs for Chagas disease, benznidazole and nifurtimox...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nara, Takeshi, Nakagawa, Yukari, Tsuganezawa, Keiko, Yuki, Hitomi, Sekimata, Katsuhiko, Koyama, Hiroo, Ogawa, Naoko, Honma, Teruki, Shirouzu, Mikako, Fukami, Takehiro, Matsuo, Yuichi, Inaoka, Daniel Ken, Kita, Kiyoshi, Tanaka, Akiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861437/ https://www.ncbi.nlm.nih.gov/pubmed/33539347 http://dx.doi.org/10.1371/journal.pone.0243855

Ejemplares similares

Structural Basis of Activin Receptor-Like Kinase 2 (R206H) Inhibition by Bis-heteroaryl Pyrazole-Based Inhibitors for the Treatment of Fibrodysplasia Ossificans Progressiva Identified by the Integration of Ligand-Based and Structure-Based Drug Design Approaches
por: Sato, Tomohiro, et al.
Publicado: (2020)

Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors
por: Yamashita, Tetsuo, et al.
Publicado: (2018)

Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase
por: Shimizu, Hideaki, et al.
Publicado: (2019)

Pharmacophore Modeling for Anti-Chagas Drug Design Using the Fragment Molecular Orbital Method
por: Yoshino, Ryunosuke, et al.
Publicado: (2015)

Regulation of succinate-ubiquinone reductase and fumarate reductase activities in human complex II by phosphorylation of its flavoprotein subunit
por: Tomitsuka, Eriko, et al.
Publicado: (2009)

Structure–Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2
por: Niwa, Hideaki, et al.
Publicado: (2022)

UbiN, a novel Rhodobacter capsulatus decarboxylative hydroxylase involved in aerobic ubiquinone biosynthesis
por: Nagatani, Haruka, et al.
Publicado: (2023)

RegB Kinase Activity Is Controlled in Part by Monitoring the Ratio of Oxidized to Reduced Ubiquinones in the Ubiquinone Pool
por: Wu, Jiang, et al.
Publicado: (2010)

Reduction of Hydrophilic Ubiquinones by the Flavin in Mitochondrial NADH:Ubiquinone Oxidoreductase (Complex I) and Production of Reactive Oxygen Species
por: King, Martin S., et al.
Publicado: (2009)

In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease
por: Yoshino, Ryunosuke, et al.
Publicado: (2017)

Computational Identification and Analysis of Ubiquinone-Binding Proteins
por: Lu, Chang, et al.
Publicado: (2020)

Acute Chagas disease in El Salvador 2000-2012 - Need for surveillance and control
por: Sasagawa, Emi, et al.
Publicado: (2014)

Nonspecific resistance to bacterial infections. Enhancement by ubiquinone-8
Publicado: (1978)

Phylogenetic ubiquity of the effects of altered ubiquinone biosynthesis on survival
por: Hekimi, Siegfried, et al.
Publicado: (2011)

Origin and Evolution of the Sodium -Pumping NADH: Ubiquinone Oxidoreductase
por: Reyes-Prieto, Adrian, et al.
Publicado: (2014)

Molecular Mechanisms Associated with the Induction of Ubiquinone by Peroxisome Proliferators
por: Khan, Seher Akhtar
Publicado: (2009)

Crystal structures of the S6K1 kinase domain in complexes with inhibitors
por: Niwa, Hideaki, et al.
Publicado: (2014)

Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria
por: Inaoka, Daniel Ken, et al.
Publicado: (2015)

Plastoquinone and Ubiquinone in Plants: Biosynthesis, Physiological Function and Metabolic Engineering
por: Liu, Miaomiao, et al.
Publicado: (2016)

A Journey across Genomes Uncovers the Origin of Ubiquinone in Cyanobacteria
por: Degli Esposti, Mauro
Publicado: (2017)

Redox potentials of ubiquinone, menaquinone, phylloquinone, and plastoquinone in aqueous solution
por: Kishi, Shinnosuke, et al.
Publicado: (2017)

Mitochondrial-targeted ubiquinone: A potential treatment for COVID-19
por: Ouyang, Lichen, et al.
Publicado: (2020)

Respiratory complex I in mitochondrial membrane catalyzes oversized ubiquinones
por: Ikunishi, Ryo, et al.
Publicado: (2023)

Kinetic study of NADPH activation using ubiquinone-rhodol fluorescent probe and an Ir(III)-complex promoter at the cell interior
por: Komatsu, Hirokazu, et al.
Publicado: (2023)

Establishment of a Monoclonal Antibody against Human NTCP That Blocks Hepatitis B Virus Infection
por: Takemori, Toshitada, et al.
Publicado: (2022)

Ubiquinone-quantum dot bioconjugates for in vitro and intracellular complex I sensing
por: Ma, Wei, et al.
Publicado: (2013)

UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis
por: White, Mark D., et al.
Publicado: (2015)

Longer Ubiquinone Side Chains Contribute to Enhanced Farnesol Resistance in Yeasts
por: Pathirana, Ruvini U., et al.
Publicado: (2020)

Quantification of NADH:ubiquinone oxidoreductase (complex I) content in biological samples
por: Ansari, Fariha, et al.
Publicado: (2021)

A unique flavoenzyme operates in ubiquinone biosynthesis in photosynthesis-related eukaryotes
por: Xu, Jing-Jing, et al.
Publicado: (2021)

Ubiquinone Binding and Reduction by Complex I—Open Questions and Mechanistic Implications
por: Galemou Yoga, Etienne, et al.
Publicado: (2021)

Diverse reaction behaviors of artificial ubiquinones in mitochondrial respiratory complex I
por: Uno, Shinpei, et al.
Publicado: (2022)

Chemistry of Lipoquinones: Properties, Synthesis, and Membrane Location of Ubiquinones, Plastoquinones, and Menaquinones
por: Braasch-Turi, Margaret M., et al.
Publicado: (2022)

CORRIGENDUM: Ubiquinone-quantum dot bioconjugates for in vitro and intracellular complex I sensing
por: Ma, Wei, et al.
Publicado: (2013)

The submitochondrial distribution of ubiquinone affects respiration in long-lived Mclk1(+/−) mice
por: Lapointe, Jérôme, et al.
Publicado: (2012)

Bridge- and Solvent-Mediated Intramolecular Electronic Communications in Ubiquinone-Based Biomolecular Wires
por: Liu, Xiao-Yuan, et al.
Publicado: (2015)

Estimating the occurrence of primary ubiquinone deficiency by analysis of large-scale sequencing data
por: Hughes, Bryan G., et al.
Publicado: (2017)

Mitochondrial ubiquinone–mediated longevity is marked by reduced cytoplasmic mRNA translation
por: Molenaars, Marte, et al.
Publicado: (2018)

In Vitro Anticancer Activity and Structural Characterization of Ubiquinones from Antrodia cinnamomea Mycelium
por: Yen, I-Chuan, et al.
Publicado: (2017)

Investigating the influence of ubiquinone blood level on the abilities of children with specific learning disorder
por: Abdelraouf, Ehab Ragaa, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_5gbln73poq5g0tngl0fb3qjdkv