Probing the aggregated effects of purifying selection per individual on 1,380 medical phenotypes in the UK Biobank

Understanding the relationship between natural selection and phenotypic variation has been a long-standing challenge in human population genetics. With the emergence of biobank-scale datasets, along with new statistical metrics to approximate strength of purifying selection at the variant level, it...

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Detalles Bibliográficos
Autores principales: Vy, Ha My T., Jordan, Daniel M., Balick, Daniel J., Do, Ron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861521/
https://www.ncbi.nlm.nih.gov/pubmed/33493176
http://dx.doi.org/10.1371/journal.pgen.1009337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861521/
https://www.ncbi.nlm.nih.gov/pubmed/33493176
http://dx.doi.org/10.1371/journal.pgen.1009337

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