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Episodic evolution of coadapted sets of amino acid sites in mitochondrial proteins

The rate of evolution differs between protein sites and changes with time. However, the link between these two phenomena remains poorly understood. Here, we design a phylogenetic approach for distinguishing pairs of amino acid sites that evolve concordantly, i.e., such that substitutions at one site...

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Detalles Bibliográficos
Autores principales: Neverov, Alexey D., Popova, Anfisa V., Fedonin, Gennady G., Cheremukhin, Evgeny A., Klink, Galya V., Bazykin, Georgii A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861529/
https://www.ncbi.nlm.nih.gov/pubmed/33493156
http://dx.doi.org/10.1371/journal.pgen.1008711