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Mitochondrial depolarization promotes calcium alternans: Mechanistic insights from a ventricular myocyte model

Mitochondria are vital organelles inside the cell and contribute to intracellular calcium (Ca(2+)) dynamics directly and indirectly via calcium exchange, ATP generation, and production of reactive oxygen species (ROS). Arrhythmogenic Ca(2+) alternans in cardiac myocytes has been observed in experime...

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Detalles Bibliográficos
Autores principales: Pandey, Vikas, Xie, Lai-Hua, Qu, Zhilin, Song, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861552/
https://www.ncbi.nlm.nih.gov/pubmed/33493168
http://dx.doi.org/10.1371/journal.pcbi.1008624