Genetic conservation of SARS-CoV-2 RNA replication complex in globally circulating isolates and recently emerged variants from humans and minks suggests minimal pre-existing resistance to remdesivir

Remdesivir (RDV) exhibits potent antiviral activity against SARS-CoV-2 and is currently the only drug approved for the treatment of COVID-19. However, little is currently known about the potential for pre-existing resistance to RDV and the possibility of SARS-CoV-2 genetic diversification that might...

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Detalles Bibliográficos
Autores principales: Martin, Ross, Li, Jiani, Parvangada, Aiyappa, Perry, Jason, Cihlar, Tomas, Mo, Hongmei, Porter, Danielle, Svarovskaia, Evguenia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862048/
https://www.ncbi.nlm.nih.gov/pubmed/33549572
http://dx.doi.org/10.1016/j.antiviral.2021.105033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862048/
https://www.ncbi.nlm.nih.gov/pubmed/33549572
http://dx.doi.org/10.1016/j.antiviral.2021.105033

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