Merkel cell carcinoma-derived exosome-shuttle miR-375 induces fibroblast polarization by inhibition of RBPJ and p53

Merkel cell carcinoma (MCC) is a highly invasive and metastatic skin cancer. While high expression of miR-375 is a characteristic of MCC, it seems not to contribute to the malignant phenotype of MCC cells. miR-375 enrichment in MCC-derived extracellular vesicles suggests its intercellular signaling...

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Detalles Bibliográficos
Autores principales: Fan, Kaiji, Spassova, Ivelina, Gravemeyer, Jan, Ritter, Cathrin, Horny, Kai, Lange, Anja, Gambichler, Thilo, Ødum, Niels, Schrama, David, Schadendorf, Dirk, Ugurel, Selma, Becker, Jürgen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862059/
https://www.ncbi.nlm.nih.gov/pubmed/33311552
http://dx.doi.org/10.1038/s41388-020-01576-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862059/
https://www.ncbi.nlm.nih.gov/pubmed/33311552
http://dx.doi.org/10.1038/s41388-020-01576-6

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