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Merkel cell carcinoma-derived exosome-shuttle miR-375 induces fibroblast polarization by inhibition of RBPJ and p53

Merkel cell carcinoma (MCC) is a highly invasive and metastatic skin cancer. While high expression of miR-375 is a characteristic of MCC, it seems not to contribute to the malignant phenotype of MCC cells. miR-375 enrichment in MCC-derived extracellular vesicles suggests its intercellular signaling...

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Detalles Bibliográficos
Autores principales:	Fan, Kaiji, Spassova, Ivelina, Gravemeyer, Jan, Ritter, Cathrin, Horny, Kai, Lange, Anja, Gambichler, Thilo, Ødum, Niels, Schrama, David, Schadendorf, Dirk, Ugurel, Selma, Becker, Jürgen C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862059/ https://www.ncbi.nlm.nih.gov/pubmed/33311552 http://dx.doi.org/10.1038/s41388-020-01576-6

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