A novel UBE2T inhibitor suppresses Wnt/β-catenin signaling hyperactivation and gastric cancer progression by blocking RACK1 ubiquitination

Dysregulation of the Wnt/β-catenin signaling pathway is critically involved in gastric cancer (GC) progression. However, current Wnt pathway inhibitors being studied in preclinical or clinical settings for other cancers such as colorectal and pancreatic cancers are either too cytotoxic or insufficie...

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Detalles Bibliográficos
Autores principales: Yu, Zeyuan, Jiang, Xiangyan, Qin, Long, Deng, Haixiao, Wang, Jianli, Ren, Wen, Li, Hongbin, Zhao, Lei, Liu, Huanxiang, Yan, Hong, Shi, Wengui, Wang, Qi, Luo, Changjiang, Long, Bo, Zhou, Huinian, Sun, Hui, Jiao, Zuoyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862066/
https://www.ncbi.nlm.nih.gov/pubmed/33323973
http://dx.doi.org/10.1038/s41388-020-01572-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862066/
https://www.ncbi.nlm.nih.gov/pubmed/33323973
http://dx.doi.org/10.1038/s41388-020-01572-w

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