Cargando…

DMPK mRNA Expression in Human Brain Tissue Throughout the Lifespan

OBJECTIVE: Myotonic dystrophy is a multisystem disorder caused by a trinucleotide repeat expansion on the myotonic dystrophy protein kinase (DMPK) gene. To determine whether wildtype DMPK expression patterns vary as a function of age, we analyzed DMPK expression in the brain from 99 donors ranging f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Langbehn, Kathleen E., Carlson-Stadler, Zoe, van der Plas, Ellen, Hefti, Marco M., Dawson, Jeffrey D., Moser, David J., Nopoulos, Peggy C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862092/ https://www.ncbi.nlm.nih.gov/pubmed/33575482 http://dx.doi.org/10.1212/NXG.0000000000000537

Ejemplares similares

Variant repeats within the DMPK CTG expansion protect function in myotonic dystrophy type 1
por: Miller, Jacob N., et al.
Publicado: (2020)

Neurofilament Light Protein as a Potential Blood Biomarker for Huntington's Disease in Children
por: Byrne, Lauren M., et al.
Publicado: (2022)

Developmental Trajectory of Height, Weight, and BMI in Children and Adolescents at Risk for Huntington’s Disease: Effect of mHTT on Growth
por: Tereshchenko, Alexander, et al.
Publicado: (2020)

Behavioral Deficits in Juvenile Onset Huntington’s Disease
por: Langbehn, Kathleen E., et al.
Publicado: (2020)

Blood-Based Markers of Neuronal Injury in Adult-Onset Myotonic Dystrophy Type 1
por: van der Plas, Ellen, et al.
Publicado: (2022)

DDX6 regulates sequestered nuclear CUG-expanded DMPK-mRNA in dystrophia myotonica type 1
por: Pettersson, Olof J., et al.
Publicado: (2014)

Early Pediatric Chronic Kidney Disease is Associated with Brain Volumetric Gray Matter Abnormalities
por: Solomon, Matthew, et al.
Publicado: (2020)

Behavioral features in child and adolescent huntingtin gene‐mutation carriers
por: Reasoner, Erin E., et al.
Publicado: (2022)

Expanded DMPK repeats in dizygotic twins referred for diagnosis of autism versus absence of expanded DMPK repeats at screening of 330 children with autism
por: Musova, Zuzana, et al.
Publicado: (2016)

Sense and Antisense DMPK RNA Foci Accumulate in DM1 Tissues during Development
por: Michel, Lise, et al.
Publicado: (2015)

Docosahexaenoic Acid and Cognition throughout the Lifespan
por: Weiser, Michael J., et al.
Publicado: (2016)

The effects of oral clefts on hospital use throughout the lifespan
por: Wehby, George L, et al.
Publicado: (2012)

Audiovisual Simultaneity Judgment and Rapid Recalibration throughout the Lifespan
por: Noel, Jean-Paul, et al.
Publicado: (2016)

Epigenetics of the myotonic dystrophy-associated DMPK gene neighborhood
por: Buckley, Lauren, et al.
Publicado: (2016)

AON-induced splice-switching and DMPK pre-mRNA degradation as potential therapeutic approaches for Myotonic Dystrophy type 1
por: Stepniak-Konieczna, Ewa, et al.
Publicado: (2020)

Associations between neurofilament light chain protein, brain structure and chronic kidney disease
por: van der Plas, Ellen, et al.
Publicado: (2022)

Cellular correlates of cortical thinning throughout the lifespan
por: Vidal-Pineiro, Didac, et al.
Publicado: (2020)

The Neurodevelopmental Hypothesis of Huntington’s Disease
por: van der Plas, Ellen, et al.
Publicado: (2020)

Neurocognitive Features of Motor Premanifest Individuals With Myotonic Dystrophy Type 1
por: van der Plas, Ellen, et al.
Publicado: (2021)

Cooperation meets competition in microRNA-mediated DMPK transcript regulation
por: Koscianska, Edyta, et al.
Publicado: (2015)

DMPK hypermethylation in sperm cells of myotonic dystrophy type 1 patients
por: Yanovsky-Dagan, Shira, et al.
Publicado: (2021)

Recommendations for Improving Women's Bone Health Throughout the Lifespan
por: McPhee, Carolyn, et al.
Publicado: (2022)

Editorial: Fostering sustainable career throughout lifespan of employees
por: Savanevičienė, Asta, et al.
Publicado: (2023)

Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan
por: Bomba-Warczak, Ewa K., et al.
Publicado: (2023)

Bruxism Throughout the Lifespan and Variants in MMP2, MMP9 and COMT
por: Vieira, Alexandre R., et al.
Publicado: (2020)

Cognitive Deficits, Apathy, and Hypersomnolence Represent the Core Brain Symptoms of Adult-Onset Myotonic Dystrophy Type 1
por: Miller, Jacob N., et al.
Publicado: (2021)

Continuous Aging of the Human DNA Methylome Throughout the Human Lifespan
por: Johansson, Åsa, et al.
Publicado: (2013)

Community Resilience throughout the Lifespan – The Potential Contribution of Healthy Elders
por: Cohen, Odeya, et al.
Publicado: (2016)

Physical activity continuum throughout the lifespan: Is exercise medicine or what?
por: Cheng, Sulin, et al.
Publicado: (2016)

The differential spatiotemporal expression pattern of shelterin genes throughout lifespan
por: Wagner, Kay-Dietrich, et al.
Publicado: (2017)

Genetic risk for Alzheimer disease affects the brain throughout the lifespan
por: Linden, David E.J.
Publicado: (2020)

Stress and Cardiometabolic Disease Risk for Indigenous Populations throughout the Lifespan
por: Lewis, Melissa E., et al.
Publicado: (2021)

The Functional Foundations of Episodic Memory Remain Stable Throughout the Lifespan
por: Vidal-Piñeiro, Didac, et al.
Publicado: (2020)

How Action Shapes Body Ownership Momentarily and Throughout the Lifespan
por: Liesner, Marvin, et al.
Publicado: (2021)

Clonal behaviour of myogenic precursor cells throughout the vertebrate lifespan
por: Hughes, Simon M., et al.
Publicado: (2022)

Single molecule poly(A) tail-seq shows LARP4 opposes deadenylation throughout mRNA lifespan with most impact on short tails
por: Mattijssen, Sandy, et al.
Publicado: (2020)

Role of Myotonic Dystrophy Protein Kinase (DMPK) in Glucose Homeostasis and Muscle Insulin Action
por: Llagostera, Esther, et al.
Publicado: (2007)

DMPK gene DNA methylation levels are associated with muscular and respiratory profiles in DM1
por: Légaré, Cécilia, et al.
Publicado: (2019)

High Resolution Analysis of DMPK Hypermethylation and Repeat Interruptions in Myotonic Dystrophy Type 1
por: Rasmussen, Astrid, et al.
Publicado: (2022)

Brainstem and striatal volume changes are detectable in under 1 year and predict motor decline in spinocerebellar ataxia type 1
por: Koscik, Timothy R, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_il8nhl2jicsro6gsevvshvkpb3