UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance

UBE2O, an E2/E3 hybrid ubiquitin-protein ligase, has been implicated in the regulation of adipogenesis, erythroid differentiation, and tumor proliferation. However, its role in cancer radioresistance remains completely unknown. Here, we uncover that UBE2O interacts and targets Mxi1 for ubiquitinatio...

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Detalles Bibliográficos
Autores principales: Huang, Yumei, Yang, Xijie, Lu, Yanwei, Zhao, Ye, Meng, Rui, Zhang, Sheng, Dong, Xiaorong, Xu, Shuangbing, Wu, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862231/
https://www.ncbi.nlm.nih.gov/pubmed/32901121
http://dx.doi.org/10.1038/s41418-020-00616-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862231/
https://www.ncbi.nlm.nih.gov/pubmed/32901121
http://dx.doi.org/10.1038/s41418-020-00616-8

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