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Mechanism of pore opening in the calcium-activated chloride channel TMEM16A
The anion channel TMEM16A is activated by intracellular Ca(2+) in a highly cooperative process. By combining electrophysiology and autocorrelation analysis, we investigated the mechanism of channel activation and the concurrent rearrangement of the gate in the narrow part of the pore. Features in th...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862263/ https://www.ncbi.nlm.nih.gov/pubmed/33542228 http://dx.doi.org/10.1038/s41467-020-20788-8 |