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Sensitive mass spectrometric determination of kinin-kallikrein system peptides in light of COVID-19

The outbreak of COVID-19 has raised interest in the kinin–kallikrein system. Viral blockade of the angiotensin-converting enzyme 2 impedes degradation of the active kinin des-Arg(9)-bradykinin, which thus increasingly activates bradykinin receptors known to promote inflammation, cough, and edema—sym...

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Detalles Bibliográficos
Autores principales: Gangnus, Tanja, Burckhardt, Bjoern B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862273/
https://www.ncbi.nlm.nih.gov/pubmed/33542252
http://dx.doi.org/10.1038/s41598-021-82191-7