Cargando…

TonEBP regulates the hyperosmotic expression of aquaporin 1 and 5 in the intervertebral disc

The central region of the intervertebral disc (IVD) is rich in proteoglycans, leading to a hyperosmotic environment, which fluctuates with daily loading. The cells of the nucleus pulposus (NP cells) have adapted to this environment via the function of tonicity enhancer binding protein (TonEBP), and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Snuggs, J. W., Tessier, S., Bunning, R. A. B., Shapiro, I. M., Risbud, M. V., Le Maitre, C. L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862284/ https://www.ncbi.nlm.nih.gov/pubmed/33542263 http://dx.doi.org/10.1038/s41598-021-81838-9

Ejemplares similares

Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus
por: Liu, Chao, et al.
Publicado: (2017)

Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: Evolving role of TonEBP
por: Johnson, Zariel I., et al.
Publicado: (2014)

TonEBP and SMIT expression in human placenta
por: Shin, Jung-A, et al.
Publicado: (2012)

TonEBP suppresses IL-10-mediated immunomodulation
por: Choi, Soo Youn, et al.
Publicado: (2016)

Nucleus pulposus primary cilia alter their length in response to changes in extracellular osmolarity but do not control TonEBP-mediated osmoregulation
por: Choi, Hyowon, et al.
Publicado: (2019)

Genistein‐Calcitriol Mitigates Hyperosmotic Stress‐Induced TonEBP, CFTR Dysfunction, VDR Degradation and Inflammation in Dry Eye Disease
por: Panigrahi, Trailokyanath, et al.
Publicado: (2020)

Modulation of TonEBP activity by SUMO modification in response to hypertonicity
por: Kim, Jeong-Ah, et al.
Publicado: (2014)

Aquaporin expression in the human and canine intervertebral disc during maturation and degeneration
por: Snuggs, Joseph W., et al.
Publicado: (2019)

Transcriptional Regulator TonEBP Mediates Oxidative Damages in Ischemic Kidney Injury
por: Yoo, Eun Jin, et al.
Publicado: (2019)

TonEBP modulates the protective effect of taurine in ischemia-induced cytotoxicity in cardiomyocytes
por: Yang, Y J, et al.
Publicado: (2015)

TonEBP Promotes β-Cell Survival under ER Stress by Enhancing Autophagy
por: Kang, Hyun Je, et al.
Publicado: (2020)

Osmoprotective Transcription Factor NFAT5/TonEBP Modulates Nuclear Factor-κB Activity
por: Roth, Isabelle, et al.
Publicado: (2010)

TonEBP/NFAT5 regulates ACTBL2 expression in biomechanically activated vascular smooth muscle cells
por: Hödebeck, Maren, et al.
Publicado: (2014)

TonEBP suppresses adipogenesis and insulin sensitivity by blocking epigenetic transition of PPARγ2
por: Ho Lee, Jun, et al.
Publicado: (2015)

TonEBP Suppresses the HO-1 Gene by Blocking Recruitment of Nrf2 to Its Promoter
por: Yoo, Eun Jin, et al.
Publicado: (2019)

TonEBP Regulates PCNA Polyubiquitination in Response to DNA Damage through Interaction with SHPRH and USP1
por: Kang, Hyun Je, et al.
Publicado: (2019)

Involvement of TonEBP/NFAT5 in osmoadaptative response of human retinal pigmented epithelial cells to hyperosmolar stress
por: Libert, Sarah, et al.
Publicado: (2016)

LPS-induced NFκB enhanceosome requires TonEBP/NFAT5 without DNA binding
por: Lee, Hwan Hee, et al.
Publicado: (2016)

TonEBP/NFAT5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beiging
por: Lee, Hwan Hee, et al.
Publicado: (2019)

Focal adhesion kinase regulates the activity of the osmosensitive transcription factor TonEBP/NFAT5 under hypertonic conditions
por: Neuhofer, Wolfgang, et al.
Publicado: (2014)

TonEBP in dendritic cells mediates pro-inflammatory maturation and Th1/Th17 responses
por: Ye, Byeong Jin, et al.
Publicado: (2020)

Transcription Factor TonEBP Stimulates Hyperosmolality-Dependent Arginine Vasopressin Gene Expression in the Mouse Hypothalamus
por: Kim, Dong Hee, et al.
Publicado: (2021)

TonEBP/NFAT5 haploinsufficiency attenuates hippocampal inflammation in high-fat diet/streptozotocin-induced diabetic mice
por: Lee, Jong Youl, et al.
Publicado: (2017)

Aquaporin 1 and 5 expression decreases during human intervertebral disc degeneration: novel HIF-1-mediated regulation of aquaporins in NP cells
por: Johnson, Zariel I., et al.
Publicado: (2015)

BMP-2 and TGF-β Stimulate Expression of β1,3-Glucuronosyl Transferase 1 (GlcAT-1) in Nucleus Pulposus Cells Through AP1, TonEBP, and Sp1: Role of MAPKs
por: Hiyama, Akihiko, et al.
Publicado: (2010)

TonEBP suppresses adipocyte differentiation via modulation of early signaling in 3T3-L1 cells
por: Kim, Soo Jin, et al.
Publicado: (2016)

TonEBP recognizes R-loops and initiates m6A RNA methylation for R-loop resolution
por: Kang, Hyun Je, et al.
Publicado: (2020)

TonEBP in Myeloid Cells Promotes Obesity-Induced Insulin Resistance and Inflammation Through Adipose Tissue Remodeling
por: Lee, Hwan Hee, et al.
Publicado: (2022)

TonEBP Haploinsufficiency Attenuates Microglial Activation and Memory Deficits in Middle-Aged and Amyloid β Oligomer-Treated Mice
por: Lee, Jong Youl, et al.
Publicado: (2023)

The TLR-2/TonEBP signaling pathway regulates 29-kDa fibronectin fragment-dependent expression of matrix metalloproteinases
por: Hwang, Hyun Sook, et al.
Publicado: (2021)

Osmolyte regulation by TonEBP/NFAT5 during anoxia-recovery and dehydration–rehydration stresses in the freeze-tolerant wood frog (Rana sylvatica)
por: Al-attar, Rasha, et al.
Publicado: (2017)

Microglial TonEBP mediates LPS-induced inflammation and memory loss as transcriptional cofactor for NF-κB and AP-1
por: Jeong, Gyu Won, et al.
Publicado: (2020)

NFAT5/TonEBP Limits Pulmonary Vascular Resistance in the Hypoxic Lung by Controlling Mitochondrial Reactive Oxygen Species Generation in Arterial Smooth Muscle Cells
por: Laban, Hebatullah, et al.
Publicado: (2021)

Immunohistochemical analysis of protein expression in formalin fixed paraffin embedded human intervertebral disc tissues
por: Binch, Abbie, et al.
Publicado: (2020)

L‐type Voltage‐Gated calcium channels partly mediate Mechanotransduction in the intervertebral disc
por: Poillot, Philip, et al.
Publicado: (2022)

Mediator of DNA Damage Checkpoint 1 (MDC1) Contributes to High NaCl-Induced Activation of the Osmoprotective Transcription Factor TonEBP/OREBP
por: Kunin, Margarita, et al.
Publicado: (2010)

Mesenchymal stem cell therapies for intervertebral disc degeneration: Consideration of the degenerate niche
por: Vickers, Louise, et al.
Publicado: (2019)

High NaCl–induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization
por: Gallazzini, Morgan, et al.
Publicado: (2011)

Injectable biomaterial induces regeneration of the intervertebral disc in a caprine loaded disc culture model
por: Snuggs, Joseph W., et al.
Publicado: (2023)

Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration
por: Le Maitre, Christine Lyn, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_u62bqdnacodt538qrrqane4ai0