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SPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation

In adult tissue, stem and progenitor cells must tightly regulate the balance between proliferation and differentiation to sustain homeostasis. How this exquisite balance is achieved is an area of active investigation. Here, we show that epidermal genes, including ~30% of induced differentiation gene...

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Detalles Bibliográficos
Autores principales: Li, Jingting, Xu, Xiaojun, Tiwari, Manisha, Chen, Yifang, Fuller, Mackenzie, Bansal, Varun, Tamayo, Pablo, Das, Soumita, Ghosh, Pradipta, Sen, George L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862286/
https://www.ncbi.nlm.nih.gov/pubmed/33542242
http://dx.doi.org/10.1038/s41467-021-21067-w