Full-length in meso structure and mechanism of rat kynurenine 3-monooxygenase inhibition

The structural mechanisms of single-pass transmembrane enzymes remain elusive. Kynurenine 3-monooxygenase (KMO) is a mitochondrial protein involved in the eukaryotic tryptophan catabolic pathway and is linked to various diseases. Here, we report the mammalian full-length structure of KMO in its memb...

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Detalles Bibliográficos
Autores principales: Mimasu, Shinya, Yamagishi, Hiroaki, Kubo, Satoshi, Kiyohara, Mie, Matsuda, Toshihiro, Yahata, Toshiko, Thomson, Heather A., Hupp, Christopher D., Liu, Julie, Okuda, Takao, Kakefuda, Kenichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862291/
https://www.ncbi.nlm.nih.gov/pubmed/33542467
http://dx.doi.org/10.1038/s42003-021-01666-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862291/
https://www.ncbi.nlm.nih.gov/pubmed/33542467
http://dx.doi.org/10.1038/s42003-021-01666-5

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