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Gating the pore of the calcium-activated chloride channel TMEM16A
The binding of cytoplasmic Ca(2+) to the anion-selective channel TMEM16A triggers a conformational change around its binding site that is coupled to the release of a gate at the constricted neck of an hourglass-shaped pore. By combining mutagenesis, electrophysiology, and cryo-electron microscopy, w...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862301/ https://www.ncbi.nlm.nih.gov/pubmed/33542223 http://dx.doi.org/10.1038/s41467-020-20787-9 |