Albumin inhibits the nuclear translocation of Smad3 via interleukin-1beta signaling in hepatic stellate cells

Activation of quiescent hepatic stellate cells (HSCs) to myofibroblasts plays a key role in liver fibrosis. We had previously shown that albumin and its derivative, R-III (a retinol-binding protein—albumin domain III fusion protein), inhibited HSC activation by sequestering retinoic acid (RA) and th...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Ji Hoon, Kim, Janghyun, Choi, So-Young, Lee, Boram, Lee, Jung-Eun, Park, Heekyung, Moon, Ji Wook, Park, Sun-Hwa, Lee, Jae Min, Lee, Hong Sik, Oh, Junseo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862402/
https://www.ncbi.nlm.nih.gov/pubmed/33542418
http://dx.doi.org/10.1038/s41598-021-82758-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862402/
https://www.ncbi.nlm.nih.gov/pubmed/33542418
http://dx.doi.org/10.1038/s41598-021-82758-4

Ejemplares similares