Comprehensive characterization and quantification of adeno associated vectors by size exclusion chromatography and multi angle light scattering

Adeno associated virus (AAV) capsids are a leading modality for in vivo gene delivery. Complete and precise characterization of capsid particles, including capsid and vector genome concentration, is necessary to safely and efficaciously dose patients. Size exclusion chromatography (SEC) coupled to m...

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Detalles Bibliográficos
Autores principales: McIntosh, Nicole L., Berguig, Geoffrey Y., Karim, Omair A., Cortesio, Christa L., De Angelis, Rolando, Khan, Ayesha A., Gold, Daniel, Maga, John A., Bhat, Vikas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862616/
https://www.ncbi.nlm.nih.gov/pubmed/33542328
http://dx.doi.org/10.1038/s41598-021-82599-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862616/
https://www.ncbi.nlm.nih.gov/pubmed/33542328
http://dx.doi.org/10.1038/s41598-021-82599-1

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