Targeted attenuation of elevated histone marks at SNCA alleviates α‐synuclein in Parkinson's disease

Epigenetic deregulation of α‐synuclein plays a key role in Parkinson’s disease (PD). Analysis of the SNCA promoter using the ENCODE database revealed the presence of important histone post‐translational modifications (PTMs) including transcription‐promoting marks, H3K4me3 and H3K27ac, and repressive...

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Detalles Bibliográficos
Autores principales: Guhathakurta, Subhrangshu, Kim, Jinil, Adams, Levi, Basu, Sambuddha, Song, Min Kyung, Adler, Evan, Je, Goun, Fiadeiro, Mariana Bernardo, Kim, Yoon‐Seong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863397/
https://www.ncbi.nlm.nih.gov/pubmed/33428332
http://dx.doi.org/10.15252/emmm.202012188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863397/
https://www.ncbi.nlm.nih.gov/pubmed/33428332
http://dx.doi.org/10.15252/emmm.202012188

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