Cargando…

Targeted attenuation of elevated histone marks at SNCA alleviates α‐synuclein in Parkinson's disease

Epigenetic deregulation of α‐synuclein plays a key role in Parkinson’s disease (PD). Analysis of the SNCA promoter using the ENCODE database revealed the presence of important histone post‐translational modifications (PTMs) including transcription‐promoting marks, H3K4me3 and H3K27ac, and repressive...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guhathakurta, Subhrangshu, Kim, Jinil, Adams, Levi, Basu, Sambuddha, Song, Min Kyung, Adler, Evan, Je, Goun, Fiadeiro, Mariana Bernardo, Kim, Yoon‐Seong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863397/ https://www.ncbi.nlm.nih.gov/pubmed/33428332 http://dx.doi.org/10.15252/emmm.202012188

Ejemplares similares

Regulation of Αlpha-Synuclein Gene (SNCA) by Epigenetic Modifier TET1 in Parkinson Disease
por: Guhathakurta, Subhrangshu, et al.
Publicado: (2022)

A novel tool for monitoring endogenous alpha-synuclein transcription by NanoLuciferase tag insertion at the 3′end using CRISPR-Cas9 genome editing technique
por: Basu, Sambuddha, et al.
Publicado: (2017)

Hypomethylation of intron1 of α-synuclein gene does not correlate with Parkinson’s disease
por: Guhathakurta, Subhrangshu, et al.
Publicado: (2017)

A novel extended form of alpha-synuclein 3′UTR in the human brain
por: Je, Goun, et al.
Publicado: (2018)

Transcriptional mutagenesis by 8-oxodG in α-synuclein aggregation and the pathogenesis of Parkinson's disease
por: Basu, Sambuddha, et al.
Publicado: (2015)

Transcriptional mutagenesis of α-synuclein caused by DNA oxidation in Parkinson’s disease pathogenesis
por: Basu, Sambuddha, et al.
Publicado: (2023)

Precise epigenomic editing with a SunTag-based modular epigenetic toolkit
por: Guhathakurta, Subhrangshu, et al.
Publicado: (2022)

Salivary total α-synuclein, oligomeric α-synuclein and SNCA variants in Parkinson’s disease patients
por: Kang, Wenyan, et al.
Publicado: (2016)

SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex
por: Brown, Jennifer L., et al.
Publicado: (2022)

Genetic Variants of the α-Synuclein Gene SNCA Are Associated with Multiple System Atrophy
por: Al-Chalabi, Ammar, et al.
Publicado: (2009)

Snca-GFP Knock-In Mice Allows Tracking the Endogenous α-Synuclein in Action
por: Er, Safak
Publicado: (2021)

A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity
por: Suresh, S. N., et al.
Publicado: (2017)

Network Analysis Implicates Alpha-Synuclein (Snca) in the Regulation of Ovariectomy-Induced Bone Loss
por: Calabrese, Gina, et al.
Publicado: (2016)

New SNCA mutation and structures of α-synuclein filaments from juvenile-onset synucleinopathy
por: Yang, Yang, et al.
Publicado: (2023)

The Impact of SNCA Variations and Its Product Alpha-Synuclein on Non-Motor Features of Parkinson’s Disease
por: Magistrelli, Luca, et al.
Publicado: (2021)

Linking the phenotype of SNCA Triplication with PET-MRI imaging pattern and alpha-synuclein CSF seeding
por: Wurster, Isabel, et al.
Publicado: (2022)

Alpha‐synuclein mRNA isoform formation and translation affected by polymorphism in the human SNCA 3ʹUTR
por: Barrie, Elizabeth S., et al.
Publicado: (2018)

Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models
por: Prieto Huarcaya, Susy, et al.
Publicado: (2022)

Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells
por: Oliveira, L M A, et al.
Publicado: (2015)

The SNCA-Rep1 Polymorphic Locus: Association with the Risk of Parkinson’s Disease and SNCA Gene Methylation
por: Iakovenko, E. V., et al.
Publicado: (2020)

Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human α-synuclein in transgenic mouse brain
por: Cronin, Kenneth D., et al.
Publicado: (2009)

SNCA Triplication Parkinson's Patient's iPSC-derived DA Neurons Accumulate α-Synuclein and Are Susceptible to Oxidative Stress
por: Byers, Blake, et al.
Publicado: (2011)

A novel resource for studying function and dysfunction of α-synuclein: mouse lines for modulation of endogenous Snca gene expression
por: Ninkina, Natalia, et al.
Publicado: (2015)

Piperine promotes autophagy flux by P2RX4 activation in SNCA/α-synuclein-induced Parkinson disease model
por: Li, Ruolin, et al.
Publicado: (2021)

α‐Synuclein antisense transcript SNCA‐AS1 regulates synapses‐ and aging‐related genes suggesting its implication in Parkinson's disease
por: Rey, Federica, et al.
Publicado: (2021)

The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson’s disease
por: Lau, Heather H. C., et al.
Publicado: (2023)

SNCA-AS1 in aging and Parkinson’s disease
por: Carelli, Stephana, et al.
Publicado: (2022)

Generation of two human induced pluripotent stem cell lines (iPSCs) with mutations of the α-synuclein (SNCA) gene associated with Parkinson’s disease; the A53T mutation (LCSBi003) and a triplication of the SNCA gene (LCSBi007)
por: Novak, Gabriela, et al.
Publicado: (2021)

Immunisation with UB-312 in the Thy1SNCA mouse prevents motor performance deficits and oligomeric α-synuclein accumulation in the brain and gut
por: Nimmo, Jacqui T., et al.
Publicado: (2021)

Striatal-Inoculation of α-Synuclein Preformed Fibrils Aggravated the Phenotypes of REM Sleep without Atonia in A53T BAC-SNCA Transgenic Mice
por: Okuda, Shinya, et al.
Publicado: (2022)

Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation
por: Kiely, Aoife P., et al.
Publicado: (2015)

Alpha‐synuclein dynamics in induced pluripotent stem cell‐derived dopaminergic neurons from a Parkinson’s disease patient (PARK4) with SNCA triplication
por: Fukusumi, Hayato, et al.
Publicado: (2021)

Variants in the SNCA Locus Are Associated With the Progression of Parkinson's Disease
por: Luo, Ningdi, et al.
Publicado: (2019)

Hyposmia Is Associated with RBD for PD Patients with Variants of SNCA
por: Li, Yuanyuan, et al.
Publicado: (2017)

Prognostic significance of SNCA and its methylation in bladder cancer
por: Wu, Zhengcun, et al.
Publicado: (2022)

Neuronal SNCA transcription during Lewy body formation
por: Kon, Tomoya, et al.
Publicado: (2023)

On your histone mark, SET, methylate!
por: Binda, Olivier
Publicado: (2013)

Modeling native and seeded Synuclein aggregation and related cellular dysfunctions in dopaminergic neurons derived by a new set of isogenic iPSC lines with SNCA multiplications
por: Iannielli, Angelo, et al.
Publicado: (2022)

Evaluation of the Role of SNCA Variants in Survival without Neurological Disease
por: Heckman, Michael G., et al.
Publicado: (2012)

Mutations in PRKN and SNCA Genes Important for the Progress of Parkinson’s Disease
por: Oczkowska, Anna, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_g30rf4l87u69dmevou89m9ltvt