Mithramycin induces promoter reprogramming and differentiation of rhabdoid tumor

Rhabdoid tumor (RT) is a pediatric cancer characterized by the inactivation of SMARCB1, a subunit of the SWI/SNF chromatin remodeling complex. Although this deletion is the known oncogenic driver, there are limited effective therapeutic options for these patients. Here we use unbiased screening of c...

Descripción completa

Detalles Bibliográficos
Autores principales: Chasse, Maggie H, Johnson, Benjamin K, Boguslawski, Elissa A, Sorensen, Katie M, Rosien, Jessica E, Kang, Min H, Reynolds, C Patrick, Heo, Lyong, Madaj, Zachary B, Beddows, Ian, Foxa, Gabrielle E, Kitchen‐Goosen, Susan M, Williams, Bart O, Triche, Timothy J, Grohar, Patrick J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863405/
https://www.ncbi.nlm.nih.gov/pubmed/33332735
http://dx.doi.org/10.15252/emmm.202012640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863405/
https://www.ncbi.nlm.nih.gov/pubmed/33332735
http://dx.doi.org/10.15252/emmm.202012640

Ejemplares similares