Neuron type‐specific increase in lamin B1 contributes to nuclear dysfunction in Huntington’s disease

Lamins are crucial proteins for nuclear functionality. Here, we provide new evidence showing that increased lamin B1 levels contribute to the pathophysiology of Huntington’s disease (HD), a CAG repeat‐associated neurodegenerative disorder. Through fluorescence‐activated nuclear suspension imaging, w...

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Detalles Bibliográficos
Autores principales: Alcalá‐Vida, Rafael, Garcia‐Forn, Marta, Castany‐Pladevall, Carla, Creus‐Muncunill, Jordi, Ito, Yoko, Blanco, Enrique, Golbano, Arantxa, Crespí‐Vázquez, Kilian, Parry, Aled, Slater, Guy, Samarajiwa, Shamith, Peiró, Sandra, Di Croce, Luciano, Narita, Masashi, Pérez‐Navarro, Esther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863407/
https://www.ncbi.nlm.nih.gov/pubmed/33369245
http://dx.doi.org/10.15252/emmm.202012105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863407/
https://www.ncbi.nlm.nih.gov/pubmed/33369245
http://dx.doi.org/10.15252/emmm.202012105

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