NAMPT/SIRT2-mediated inhibition of the p53-p21 signaling pathway is indispensable for maintenance and hematopoietic differentiation of human iPS cells

BACKGROUND: Nicotinamide phosphoribosyltransferase (NAMPT) regulates cellular functions through the protein deacetylation activity of nicotinamide adenine dinucleotide (NAD(+))-dependent sirtuins (SIRTs). SIRTs regulate functions of histones and none-histone proteins. The role of NAMPT/SIRT pathway...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Yun, Nasri, Masoud, Dannenmann, Benjamin, Mir, Perihan, Zahabi, Azadeh, Welte, Karl, Morishima, Tatsuya, Skokowa, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863436/
https://www.ncbi.nlm.nih.gov/pubmed/33546767
http://dx.doi.org/10.1186/s13287-021-02144-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863436/
https://www.ncbi.nlm.nih.gov/pubmed/33546767
http://dx.doi.org/10.1186/s13287-021-02144-9

Ejemplares similares