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NAMPT/SIRT2-mediated inhibition of the p53-p21 signaling pathway is indispensable for maintenance and hematopoietic differentiation of human iPS cells

BACKGROUND: Nicotinamide phosphoribosyltransferase (NAMPT) regulates cellular functions through the protein deacetylation activity of nicotinamide adenine dinucleotide (NAD(+))-dependent sirtuins (SIRTs). SIRTs regulate functions of histones and none-histone proteins. The role of NAMPT/SIRT pathway...

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Detalles Bibliográficos
Autores principales:	Xu, Yun, Nasri, Masoud, Dannenmann, Benjamin, Mir, Perihan, Zahabi, Azadeh, Welte, Karl, Morishima, Tatsuya, Skokowa, Julia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863436/ https://www.ncbi.nlm.nih.gov/pubmed/33546767 http://dx.doi.org/10.1186/s13287-021-02144-9

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