Propofol Inhibits the Proliferation, Migration, and Stem-like Properties of Bladder Cancer Mainly by Suppressing the Hedgehog Pathway
Bladder cancer is one of the most common malignancies. The existence of bladder cancer stem cells (BCSCs) has been suggested to underlie bladder tumor initiation and recurrence. Propofol is a commonly used intravenous anesthetic. Here, we find that propofol can dramatically block the activation of H...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863560/ https://www.ncbi.nlm.nih.gov/pubmed/33522306 http://dx.doi.org/10.1177/0963689720985113 |
_version_ | 1783647519506432000 |
---|---|
author | Li, Gang Zhang, Xu Guo, Xiangyang Li, Yi Li, Chong |
author_facet | Li, Gang Zhang, Xu Guo, Xiangyang Li, Yi Li, Chong |
author_sort | Li, Gang |
collection | PubMed |
description | Bladder cancer is one of the most common malignancies. The existence of bladder cancer stem cells (BCSCs) has been suggested to underlie bladder tumor initiation and recurrence. Propofol is a commonly used intravenous anesthetic. Here, we find that propofol can dramatically block the activation of Hedgehog pathway in BCSCs. The propofol strongly repressed the growth of cancer cells. Attenuated proliferation and enhanced apoptosis of tumor cells were observed upon propofol stimulation. Furthermore, propofol reduced the self-renewal ability of BCSCs as well as the tumor formation. In conclusion, propofol is potentially used as a novel therapeutic agent for bladder cancer by targeting self-renewal through inhibiting Hedgehog pathway. |
format | Online Article Text |
id | pubmed-7863560 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-78635602021-02-16 Propofol Inhibits the Proliferation, Migration, and Stem-like Properties of Bladder Cancer Mainly by Suppressing the Hedgehog Pathway Li, Gang Zhang, Xu Guo, Xiangyang Li, Yi Li, Chong Cell Transplant Original Article Bladder cancer is one of the most common malignancies. The existence of bladder cancer stem cells (BCSCs) has been suggested to underlie bladder tumor initiation and recurrence. Propofol is a commonly used intravenous anesthetic. Here, we find that propofol can dramatically block the activation of Hedgehog pathway in BCSCs. The propofol strongly repressed the growth of cancer cells. Attenuated proliferation and enhanced apoptosis of tumor cells were observed upon propofol stimulation. Furthermore, propofol reduced the self-renewal ability of BCSCs as well as the tumor formation. In conclusion, propofol is potentially used as a novel therapeutic agent for bladder cancer by targeting self-renewal through inhibiting Hedgehog pathway. SAGE Publications 2021-01-31 /pmc/articles/PMC7863560/ /pubmed/33522306 http://dx.doi.org/10.1177/0963689720985113 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Article Li, Gang Zhang, Xu Guo, Xiangyang Li, Yi Li, Chong Propofol Inhibits the Proliferation, Migration, and Stem-like Properties of Bladder Cancer Mainly by Suppressing the Hedgehog Pathway |
title | Propofol Inhibits the Proliferation, Migration, and Stem-like Properties of Bladder Cancer Mainly by Suppressing the Hedgehog Pathway |
title_full | Propofol Inhibits the Proliferation, Migration, and Stem-like Properties of Bladder Cancer Mainly by Suppressing the Hedgehog Pathway |
title_fullStr | Propofol Inhibits the Proliferation, Migration, and Stem-like Properties of Bladder Cancer Mainly by Suppressing the Hedgehog Pathway |
title_full_unstemmed | Propofol Inhibits the Proliferation, Migration, and Stem-like Properties of Bladder Cancer Mainly by Suppressing the Hedgehog Pathway |
title_short | Propofol Inhibits the Proliferation, Migration, and Stem-like Properties of Bladder Cancer Mainly by Suppressing the Hedgehog Pathway |
title_sort | propofol inhibits the proliferation, migration, and stem-like properties of bladder cancer mainly by suppressing the hedgehog pathway |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863560/ https://www.ncbi.nlm.nih.gov/pubmed/33522306 http://dx.doi.org/10.1177/0963689720985113 |
work_keys_str_mv | AT ligang propofolinhibitstheproliferationmigrationandstemlikepropertiesofbladdercancermainlybysuppressingthehedgehogpathway AT zhangxu propofolinhibitstheproliferationmigrationandstemlikepropertiesofbladdercancermainlybysuppressingthehedgehogpathway AT guoxiangyang propofolinhibitstheproliferationmigrationandstemlikepropertiesofbladdercancermainlybysuppressingthehedgehogpathway AT liyi propofolinhibitstheproliferationmigrationandstemlikepropertiesofbladdercancermainlybysuppressingthehedgehogpathway AT lichong propofolinhibitstheproliferationmigrationandstemlikepropertiesofbladdercancermainlybysuppressingthehedgehogpathway |